Dysplastic nevus
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Dysplastic nevi ― A na-atụ aro biopsy maka ndị ọdịda anyanwụ.
References
Dysplastic nevus , makwaara dị ka ihe na-adịghị ahụkebe ma ọ bụ Clarks nevus, akpalitela arụmụka na dermatology na dermatopathology. Ndị dọkịta na-emekarị biopsy ụmụ irighiri ihe ndị a n'ihi na ha nwere ike ịdị ka ihe na-adịghị mma ma welite nchegbu banyere melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi , nke a makwaara dị ka atypical ma ọ bụ Clark nevi, nwere ike ibute melanoma mgbe ụfọdụ. Ihe dị ka 36% nke melanoma dị nso na dysplastic nevi. Ihe ịrịba ama na nevus dysplastic nwere ike ịghọ melanoma gụnyere ọdịdị na-adịghị mma, mgbanwe pigmenti karịa, ma ọ bụ ụcha isi awọ. Ọrịa cancer ndị a na-emekarị mgbe ha dị obere (n'ihe dị ka n'etiti afọ iri atọ) , nwere ike ịdị ọtụtụ, na-adịkarịkwa n'osisi. N'ime mkpụrụ ndụ ihe nketa, dysplastic nevi nọ n'etiti nevi benign na melanoma. Otú ọ dị, naanị 20% ruo 30% nke melanoma na-abịa site na nevi dị adị.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Melanoma bụ ụdị akpụ nke na-etolite mgbe melanocytes, mkpụrụ ndụ na-ahụ maka agba akpụkpọ ahụ, na-aghọ ọrịa kansa. Melanocytes na-esite na crest neural. Nke a pụtara na melanomas nwere ike ịmalite ọ bụghị naanị na akpụkpọ ahụ kamakwa na mpaghara ndị ọzọ ebe mkpụrụ ndụ crest neural na-akwaga, dị ka eriri afọ na ụbụrụ. Ọnụ ọgụgụ nlanarị maka ndị ọrịa nwere melanoma n'oge (ogbo 0) dị elu na 97%, ebe ọ na-adaba nke ọma ruo ihe dịka 10% maka ndị a chọpụtara na ha nwere ọrịa dị elu (ogbo IV) .
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ Cancer risk
Dị ka a na-ahụ na ndị Caucasian na United States, ndị nwere dysplastic nevi nwere ihe ize ndụ nke ịmepụta melanoma nke karịrị 10%. N'aka nke ọzọ, ndị na-enweghị dysplastic nevus nwere ihe ize ndụ nke ịmepụta melanoma nke na-erughị 1%.
○ akpachara anya maka ndị nwere dysplastic nevi
A na-atụkarị aro nyocha onwe onye maka igbochi melanoma (site n'ịchọpụta atypical nevi nke enwere ike iwepụ) ma ọ bụ maka nchọpụta mmalite nke etuto dị adị. Ndị nwere akụkọ ihe mere eme nke onwe ma ọ bụ ezinụlọ nke ọrịa kansa anụ ahụ ma ọ bụ nke ọtụtụ nevi atypical kwesịrị ịhụ onye na-ahụ maka anụ ahụ ọbụlagodi otu ugboro n'afọ iji jide n'aka na ha anaghị etolite melanoma.
Mkpebi ahụ [ABCDE] abawo uru maka inyere ndị na-ahụ maka ahụike na ndị nkịtị aka icheta njirimara bụ isi nke melanoma. N'ụzọ dị mwute maka ndị nkịtị, ọtụtụ seborrheic keratoses, ụfọdụ lentigo senilis, na ọbụna waatị nwere ike inwe àgwà [ABCDE], a pụghịkwa ịmata ọdịiche dị na melanoma.
○ [ABCDE]
Asymmetrical: Asymmetrical akpụkpọ ọnya.
Border: Ókè nke ọnya ahụ adịghị adịkarị.
Color: melanoma na-enwekarị ọtụtụ agba na-adịghị mma.
Diameter: nevi karịrị 6 mm nwere ike ịbụ melanoma karịa obere nevi.
Evolution: Evolushọn (ya bụ mgbanwe) nke nevus ma ọ bụ ọnya nwere ike igosi na ọnya ahụ na-aghọ njọ.